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5-HT2A Receptor
PsychedelicPrimary receptor psychedelics act on.
Example: Psilocybin, LSD, DMT, and mescaline are all agonists at this one receptor despite looking chemically very different — see our Antagonist entry above for the opposite case, and our LSD coverage for how one company is trying to build an approved drug around it.
What is the 5-HT2A receptor?
The primary receptor classic psychedelics act on.
Which psychedelics act on the 5-HT2A receptor?
Psilocybin, LSD, DMT, and mescaline are all agonists at this one receptor despite looking chemically very different.
Is any company building an approved drug around this receptor?
Yes — see our LSD coverage of how Definium is trying to build an approved drug (DT120) around 5-HT2A agonism.