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Autonomic Nervous System

Neuroscience

The nervous system network controlling involuntary functions — heart rate, blood pressure, digestion — largely outside conscious control.

Example: Ibogaine's effect on this system, specifically cardiac QTc prolongation, is the exact safety signal that ended a Phase 1 opioid-use-disorder trial — see the full history.

What is the autonomic nervous system?

The nervous system network controlling involuntary functions — heart rate, blood pressure, digestion — largely outside conscious control.

Why does this matter for ibogaine specifically?

Ibogaine's effect on this system, specifically cardiac QTc prolongation, is the exact safety signal that ended a Phase 1 opioid-use-disorder trial. See the full history.

Related Articles

Policy Aug 31, 2026

Ibogaine's Flagship Drug Hit a Cardiac Signal and a Lawsuit. A Different Drug Is Now Leading.

A company-by-company look at who holds ibogaine's 53 patents — and how the compound's original opioid-use-disorder program stalled over a cardiac safety signal and litigation, while a different drug, for a different disease, became the first ibogaine-class compound ever cleared for a US trial.

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