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Derealization

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A dissociative symptom in which the external world feels unreal, dreamlike, or distorted — the outward-facing counterpart to depersonalization (see entry above).

Example: Both symptoms are common enough with ketamine that clinical trials of ketamine for depression routinely screen for them using the Clinician Administered Dissociative States Scale, scored throughout each infusion.

What is derealization?

A dissociative symptom in which the external world feels unreal, dreamlike, or distorted — the outward-facing counterpart to depersonalization.

How common is derealization in ketamine trials?

Common enough that clinical trials of ketamine for depression routinely screen for it, alongside depersonalization, using the Clinician Administered Dissociative States Scale, scored throughout each infusion.