Dysphoria
RisksA state of unease, discomfort, or dissatisfaction — the opposite of euphoria, and a real risk with some dissociatives and higher doses of certain psychedelics, distinct from a full "bad trip" (see entry above).
Example: Dysphoria and dissociation are common enough side effects in ketamine-for-depression trials that researchers track them on a standardized scale throughout every infusion, specifically to separate the drug's antidepressant effect from its dissociative one.
What is dysphoria?
A state of unease, discomfort, or dissatisfaction — the opposite of euphoria, and a real risk with some dissociatives and higher doses of certain psychedelics, distinct from a full "bad trip."
How do researchers track dysphoria in ketamine trials?
Dysphoria and dissociation are common enough side effects in ketamine-for-depression trials that researchers track them on a standardized scale throughout every infusion, specifically to separate the drug's antidepressant effect from its dissociative one.