Efficacy vs. Effectiveness
ClinicalEfficacy is how well a drug works under controlled trial conditions; effectiveness is how well it works in messier real-world use. The two numbers often diverge, and real-world data usually runs lower.
Example: Oregon's real-world, non-clinical psilocybin program has produced outcome data researchers are actively comparing against clinical-trial efficacy numbers — an open test of exactly this gap.
What's the difference between efficacy and effectiveness?
Efficacy is how well a drug works under controlled trial conditions; effectiveness is how well it works in messier real-world use. The two numbers often diverge, and real-world data usually runs lower.
Is there a real-world test of this gap in psychedelics?
Oregon's real-world, non-clinical psilocybin program has produced outcome data researchers are actively comparing against clinical-trial efficacy numbers — an open test of exactly this gap.