First-Episode Psychosis
RisksThe first time a person experiences psychosis — delusions, hallucinations, or severely disorganized thinking — often in late adolescence or early adulthood.
Example: This is the specific population pharmacologist David Nichols flagged in our Permafried piece: people with an underlying predisposition toward psychosis can have a psychedelic trip trigger a first episode that was already latent, a real and narrow risk distinct from the broader "fried brain" myth.
What is first-episode psychosis?
The first time a person experiences psychosis — delusions, hallucinations, or severely disorganized thinking — often in late adolescence or early adulthood.
Can psychedelics trigger first-episode psychosis?
Pharmacologist David Nichols has flagged that people with an underlying predisposition toward psychosis can have a psychedelic trip trigger a first episode that was already latent — a real but narrow risk, distinct from the broader "fried brain" myth. See our Permafried piece.