Macrodose
PsychedelicA full, standard psychoactive dose intended to produce a complete psychedelic experience — the term exists mainly to distinguish ordinary dosing from microdosing (see entry above).
Example: COMPASS Pathways' Phase 2b trial defined its macrodose arm as 25 mg of synthetic psilocybin, a single dose that put 29.1% of treatment-resistant depression patients into remission by week 3 — compared with a 1 mg comparator dose too low to produce a full psychedelic effect.
What is a macrodose?
A full, standard psychoactive dose intended to produce a complete psychedelic experience — the term exists mainly to distinguish ordinary dosing from microdosing.
What's an example of a clinical macrodose?
Compass Pathways' Phase 2b trial defined its macrodose arm as 25 mg of synthetic psilocybin, a single dose that put 29.1% of treatment-resistant depression patients into remission by week 3 — compared with a 1 mg comparator dose too low to produce a full psychedelic effect.