MAOI (Monoamine Oxidase Inhibitor)
PharmacologyEnzyme inhibitor that prevents breakdown of DMT in the gut, enabling oral psychoactive activity in ayahuasca.
Example: This is also why MAOIs come with a real dietary restriction outside of psychedelics — combined with tyramine-rich foods (aged cheese, cured meats), they can trigger a genuine hypertensive crisis, not just a bad trip. The same MAO enzymes are involved in breaking down 2C-B, which is one reason combining the two carries real risk rather than just folklore.
What is an MAOI?
An enzyme inhibitor that prevents breakdown of DMT in the gut, enabling oral psychoactive activity in ayahuasca.
What's the dietary risk of taking an MAOI?
Combined with tyramine-rich foods (aged cheese, cured meats), MAOIs can trigger a genuine hypertensive crisis, not just a bad trip — a real dietary restriction outside of psychedelics too.
Does an MAOI interact with other psychedelics besides DMT?
Yes — the same MAO enzymes are involved in breaking down 2C-B, which is one reason combining the two carries real risk rather than just folklore.