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Microdosing
PsychedelicSub-perceptual dosing.
Example: Open-label reports are enthusiastic, but the rigorous, placebo-controlled evidence hasn't followed — a 2026 microdosed-LSD depression trial we covered looked strong in open-label testing, then failed to beat an active placebo once a real control arm was added. Worth remembering when the enthusiasm and the trial design don't match.
What is microdosing?
Taking a sub-perceptual dose of a psychedelic — too small to produce a noticeable effect.
Does controlled research support microdosing's benefits?
Not convincingly yet. Open-label reports are enthusiastic, but a 2026 microdosed-LSD depression trial we covered looked strong in open-label testing, then failed to beat an active placebo once a real control arm was added.