Tabernanthalog (TBG)
CompoundA non-hallucinogenic, non-cardiotoxic ibogaine analog engineered at UC Davis's Olson Lab. Water-soluble and synthesizable in a single step, it promotes the same kind of neuroplasticity as ibogaine — new dendrites and dendritic spines — without producing a head-twitch response in mice, the standard proxy for hallucinogenic effect. Reduced alcohol consumption and reversed stress-induced changes in animal studies; no human trials yet.
Example: The whole point of TBG is sidestepping the exact problem that stalled ibogaine's own lead drug candidate — a real cardiac safety signal that ended a Phase 1 program.
What is Tabernanthalog (TBG)?
A non-hallucinogenic, non-cardiotoxic ibogaine analog engineered at UC Davis's Olson Lab — water-soluble and synthesizable in a single step.
How is TBG different from ibogaine?
It promotes the same kind of neuroplasticity as ibogaine — new dendrites and dendritic spines — without producing a head-twitch response in mice (the standard proxy for hallucinogenic effect), and without the cardiac safety signal that stalled ibogaine's own lead drug candidate.
Has TBG been tested in humans?
Not yet — it has reduced alcohol consumption and reversed stress-induced changes in animal studies only; no human trials have been reported.