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Treatment-Resistant Depression
ClinicalDepression not responsive to treatment.
Example: This is the exact indication behind the highest-revenue branded psychiatric drugs on the market today — see our breakdown of who's actually making money on it.
What counts as treatment-resistant depression?
Generally, depression that hasn't adequately responded to at least two different antidepressant trials at an adequate dose and duration — though the exact clinical definition varies by study and regulator.
What psychedelic treatments are being studied for treatment-resistant depression?
Esketamine (Spravato) is already FDA-approved for it; psilocybin (COMP360) and 5-MeO-DMT (GH001) are both in active trials targeting the same indication.
Why is treatment-resistant depression such a major commercial target?
It's the exact indication behind the highest-revenue branded psychiatric drugs on the market today. See our breakdown of who's actually making money on it.