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A Single Psilocybin Dose Left Measurable Brain Changes a Month Later — In Healthy Volunteers, Not Patients

A new UCSF study gave 28 healthy volunteers — no depression, no prior psychedelic experience — a single 25mg dose of psilocybin and tracked their brains for a month after. EEG showed a spike in signal entropy within hours, and structural scans still showed changes a month out, with the biggest short-term entropy spikes predicting the most reported insight and well-being later. Worth naming plainly: this is healthy volunteers, not a depression trial — durable brain change correlating with subjective benefit, not proof of a clinical effect.

Read at UCSF