An 88-Person Real-World Study of Oregon's Legal Psilocybin Services Found What the Clinical Trials Found
Researchers from Bendable Therapy, Osmind, and UCSF — including psychedelic-neuroscience researcher Robin Carhart-Harris — tracked 88 people who went through Oregon's state-licensed psilocybin services between March 2024 and April 2025, outside any clinical trial. Depression, anxiety, and well-being all improved significantly 30 days after a session, holding up even among the nearly half of participants already taking psychiatric medication. Two people reported lingering visual aftereffects a day out that had resolved by 30 days; three reported psychological aftereffects at 30 days. It's naturalistic, with no control group and a small, self-selected sample — nearly half the participants traveled in from out of state — so it's not a substitute for a randomized trial, but it's an early read on whether Oregon's legal program is producing outcomes anywhere near what's shown up in clinical settings.
Read at medRxiv (preprint, not yet peer-reviewed)