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May 20, 2025 Psychedelics
Synthetic 5-MeO-DMT Showed a 55% Response Rate — Even Alongside an SSRI
Beckley Psytech's Phase IIa data on BPL-003 — intranasal synthetic 5-MeO-DMT — showed a 55% response rate the day after dosing, sustained through day 85, in patients still taking an SSRI. That's notable because SSRIs are known to blunt psychedelics by downregulating the exact receptor they work through — I wrote about that interaction here on Altitude — so a signal this strong on top of one is worth watching. Side effects were mild: nasal discomfort, nausea, headache, no serious adverse events.
Read at Beckley Psytech