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5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) Used in a Naturalistic Group Setting Is Associated With Unintended Improvements in Depression and Anxiety

Davis AK, So S, Lancelotta R, Barsuglia JP, Griffiths RR — Johns Hopkins University School of Medicine

Published in The American Journal of Drug and Alcohol Abuse

Observational survey of people who used vaporized 5-MeO-DMT ("toad medicine") in naturalistic group settings. Users reported unintended but significant improvements in self-reported depression and anxiety symptoms — not a controlled trial, but among the earliest data on the compound's effects in humans outside the lab.

Read the Full Paper at The American Journal of Drug and Alcohol Abuse