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Jan 2012 Neuroimaging Study

Neural Correlates of the Psychedelic State as Determined by fMRI Studies With Psilocybin

Carhart-Harris RL, Erritzoe D, Williams T, et al. — Imperial College London

Published in Proceedings of the National Academy of Sciences

Psilocybin Neuroimaging

One of the first modern neuroimaging studies of psilocybin — 30 volunteers scanned with task-free fMRI after IV psilocybin or placebo. Counterintuitively, psilocybin decreased blood flow and activity in brain hub regions (thalamus, cingulate cortex) rather than increasing it, reshaping how researchers think about what a psychedelic actually does to the brain.

Read the Full Paper at Proceedings of the National Academy of Sciences