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Oct 2022 Randomized Controlled Trial

Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial

Bogenschutz MP, Ross S, Bhatt S, et al. — NYU Grossman School of Medicine

Published in JAMA Psychiatry

Psilocybin Alcohol Use DisorderAddiction

93 adults with alcohol use disorder received psilocybin or diphenhydramine (active placebo) alongside 12 weeks of manualized therapy. The psilocybin group's heavy-drinking days dropped to 9.7% vs. 23.6% in the placebo group — a 13.9-point gap — with no serious adverse events in the psilocybin arm.

Read the Full Paper at JAMA Psychiatry